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Department : BIOCHEMISTRY

The Tissue Transglutaminase (TTG) test is a blood test used to detect antibodies against tissue transglutaminase, an enzyme involved in the immune response in celiac disease.

In individuals with celiac disease, ingestion of gluten triggers an immune reaction that damages the lining of the small intestine. The presence of TTG antibodies indicates this abnormal immune response and helps in diagnosing the condition.

Depending on clinical requirements, the test may include IgA, IgG, or both antibody types. It is commonly used as a screening tool and is often followed by further tests such as intestinal biopsy for confirmation.

For accurate results, it is important that the individual continues consuming gluten prior to testing.

The purpose of this test is to

• To detect TTG antibodies
• To screen for celiac disease
• To assess gluten-related immune response
• To support diagnosis of intestinal disorders
• To guide further diagnostic evaluation