IHC HER2

The IHC HER2 (Immunohistochemistry HER2) Test is a specialized laboratory test performed on tissue samples to evaluate the presence and level of HER2 (Human Epidermal Growth Factor Receptor 2) protein.

HER2 is a protein that can promote the growth of cancer cells. In some cancers, particularly breast cancer and certain gastric cancers, HER2 may be overexpressed, leading to more aggressive tumor behavior.

The purpose of this test is to:

• Detect HER2 protein expression in tissue samples
• Determine HER2 status of tumors
• Guide selection of targeted cancer therapy
• Assist in prognosis and treatment planning

IHC HER2 Test

The IHC HER2 test (Immunohistochemistry for HER2) evaluates the amount of HER2 protein present on the surface of tumor cells in a tissue sample. HER2, or human epidermal growth factor receptor 2, is a protein that can promote the growth of certain cancers.

HER2 testing is commonly performed on breast cancer tissue, and it may also be relevant in certain other cancers, such as gastric or gastroesophageal cancers. The test helps classify the tumor according to its HER2 status and can provide important information for treatment planning.

The tissue sample is treated with specific antibodies that bind to HER2 protein. A pathologist then evaluates the staining pattern and intensity. Depending on the cancer type and testing guidelines, results may be reported using categories. An equivocal result, commonly 2+, may require additional testing such as HER2 ISH/FISH.

Test Recommended for Individuals:

• Individuals diagnosed with breast cancer
• Patients with newly diagnosed invasive breast carcinoma
• People with recurrent or metastatic breast cancer requiring reassessment
• Individuals with certain gastric or gastroesophageal cancers when HER2 testing is clinically indicated
• Patients whose tumor characteristics require evaluation for HER2-targeted treatment
• Individuals advised by their oncologist or pathologist to undergo HER2 testing

FAQs

1. What does the IHC HER2 test detect?
The test detects HER2 protein expression in tumor tissue using immunohistochemistry. It helps determine whether a tumor has increased HER2 expression.

2. What do HER2 IHC scores such as 0, 1+, 2+, and 3+ mean?
The scores describe the amount and pattern of HER2 staining observed in the tumor cells. Generally, 0 and 1+ indicate no or low HER2 expression, while 3+ indicates HER2-positive overexpression. A 2+ result is usually considered equivocal and may require additional testing.

3. Why is HER2 testing important in cancer?
HER2 status can help doctors determine whether a patient may benefit from HER2-targeted therapies. Therefore, the result can play an important role in selecting an appropriate treatment strategy.