2HE4 (HUMAN EPIDIDYMIS PROTEIN 4) Test Purpose

The HE4 (Human Epididymis Protein 4) Test is performed to measure the level of HE4, a protein that may be elevated in certain types of ovarian cancer. Primarily, the test is used alongside other clinical assessments and tumor markers, such as CA-125, to evaluate the likelihood of ovarian malignancy in women with an ovarian mass. Additionally, it helps healthcare providers assess the risk of epithelial ovarian cancer and supports treatment planning. Furthermore, the test may be used to monitor treatment response and detect disease recurrence after therapy. Moreover, the HE4 Test is often included as part of the Risk of Ovarian Malignancy Algorithm (ROMA), improving the assessment of ovarian cancer risk.

2HE4 (HUMAN EPIDIDYMIS PROTEIN 4) Test is Recommended for Individuals:

• Women with a suspected ovarian mass requiring further evaluation.
• Individuals undergoing assessment for epithelial ovarian cancer.
• Women with abnormal pelvic ultrasound findings.
• Patients with elevated or abnormal CA-125 levels requiring additional evaluation.
• Women are being assessed using the Risk of Ovarian Malignancy Algorithm (ROMA).
• Patients undergoing treatment for ovarian cancer to monitor response.
• Individuals with symptoms such as persistent bloating, pelvic pain, abdominal swelling, or early satiety, when advised by a healthcare provider.
• Anyone referred by a gynecologist or oncologist for ovarian cancer risk assessment.

FAQs

1. What is the HE4 (Human Epididymis Protein 4) Test used for?
The HE4 Test measures the level of Human Epididymis Protein 4 in the blood. Additionally, it helps assess the risk of epithelial ovarian cancer, supports evaluation of ovarian masses, and monitors treatment response and recurrence.

2. Do I need to fast before the HE4 Test?
No. Fasting is generally not required before the HE4 Test. However, you should follow any specific instructions provided by your healthcare provider.

3. Does a high HE4 level always mean ovarian cancer?
No. An elevated HE4 level does not confirm ovarian cancer on its own. Instead, the results should be interpreted together with CA-125 levels, imaging studies, medical history, and other clinical findings by a healthcare professional.