HLA B27

This Test is a blood test that identifies the presence of the HLA-B27 protein, a genetic marker associated with certain autoimmune and inflammatory disorders.

HLA-B27 is strongly linked to conditions such as ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and other types of spondyloarthritis. While not everyone with HLA-B27 develops these conditions, its presence increases the likelihood and helps support diagnosis when symptoms are present.

The purpose of this test is to:

• Detect the presence of HLA-B27 genetic marker
• Support diagnosis of autoimmune and inflammatory disorders
• Help identify conditions like ankylosing spondylitis
• Assist in clinical evaluation of joint and spine disorders

HLA B27 Test

The HLA-B27 test detects the presence or absence of the HLA-B27 protein marker on the surface of white blood cells. HLA-B27 is a genetic marker associated with a group of inflammatory conditions known as spondyloarthritis.

The test is mainly used to support the diagnosis of conditions such as ankylosing spondylitis, reactive arthritis, and certain forms of uveitis. However, having HLA-B27 does not mean that a person definitely has one of these conditions. Similarly, some people with these diseases may test negative for HLA-B27.

Doctors generally interpret the result along with symptoms, physical examination, imaging studies, and other laboratory tests.

This Test is Recommended for Individuals:

• Individuals with persistent lower back pain and stiffness, particularly when symptoms begin at a younger age
• People suspected of having ankylosing spondylitis
• Individuals with symptoms suggestive of axial spondyloarthritis
• People with recurrent or unexplained uveitis (eye inflammation)
• Individuals being evaluated for reactive arthritis
• People with certain types of inflammatory joint pain or arthritis
• Individuals with a strong clinical suspicion of a spondyloarthritis-related condition

FAQs

1. What does a positive HLA-B27 test mean?
A positive result means that the HLA-B27 genetic marker is present. It can increase the likelihood of certain inflammatory conditions, but it does not confirm a diagnosis on its own.

2. Is HLA-B27 a test for ankylosing spondylitis?
HLA-B27 can support the evaluation of ankylosing spondylitis, but it is not a definitive diagnostic test. Doctors may also consider symptoms, inflammatory markers, X-rays, or MRI findings.

3. Can HLA-B27 be negative in someone with ankylosing spondylitis?
Yes. Although HLA-B27 is commonly associated with ankylosing spondylitis, some affected individuals do not carry the marker. Therefore, a negative result does not completely rule out the condition.