Hepatitis E Virus (HEV) IgM & IgG

HEPATITIS E VIRUS (HEV) IGM & IGG Test

The Hepatitis E Virus (HEV) IgM & IgG test detects two types of antibodies produced by the immune system in response to hepatitis E virus (HEV) infection.

HEV IgM generally appears during a recent or acute infection and can help identify people who may currently have hepatitis E. HEV IgG develops after exposure and can remain detectable for a longer period, helping indicate previous exposure to the virus.

This combined test may be useful when evaluating acute or previous hepatitis E infection, particularly in individuals with symptoms such as jaundice, dark urine, fatigue, nausea, vomiting, abdominal discomfort, or unexplained elevation of liver enzymes.

Results should be interpreted together with clinical symptoms, liver function tests, exposure history, and other hepatitis investigations. In selected cases, HEV RNA testing may be recommended for additional confirmation.

Test Recommended for Individuals:

• Individuals with symptoms suggestive of hepatitis E
• People with jaundice or unexplained liver enzyme elevation
• Individuals with suspected recent exposure to HEV
• People who may have consumed contaminated food or water
• Individuals being evaluated during a suspected hepatitis E outbreak
• Pregnant individuals with suspected hepatitis E, as advised by a healthcare provider
• People requiring assessment of recent or previous HEV exposure
• Patients advised by their healthcare provider to undergo hepatitis E testing

FAQs

1. What is the difference between HEV IgM and IgG?
HEV IgM generally indicates a recent or acute infection, whereas HEV IgG usually indicates previous exposure to hepatitis E and may remain detectable for a longer period.

2. What does a positive HEV IgM result mean?
A positive HEV IgM result generally suggests a recent or acute hepatitis E infection. The result should be interpreted along with symptoms, liver function tests, and other clinical findings.

3. What does a positive HEV IgG result mean?
A positive HEV IgG result generally indicates previous exposure to hepatitis E virus. It does not, by itself, confirm that an active infection is currently present. If acute infection is suspected, your healthcare provider may recommend additional testing such as HEV IgM or HEV RNA.