DOUBLE MARKER TEST

This is a prenatal screening test performed during the first trimester of pregnancy, usually between 9 and 13 weeks. It measures two important markers in the mother’s blood—Free Beta hCG and PAPP-A (Pregnancy-Associated Plasma Protein A).

The purpose of the test is to:

• Screen for chromosomal abnormalities in the fetus
• Assess risk of Down syndrome and Edwards syndrome
• Support early pregnancy screening
• Assist in decision-making for further diagnostic tests

DOUBLE MARKER TEST Test

The Double Marker Test is a prenatal blood screening test performed during early pregnancy to assess the likelihood of certain chromosomal abnormalities in the developing baby. It typically measures two biochemical markers in the mother’s blood: free beta-hCG and PAPP-A (Pregnancy-Associated Plasma Protein-A).

The results are usually combined with factors such as maternal age and ultrasound findings, particularly the nuchal translucency (NT) measurement, to calculate an individualized risk estimate for chromosomal conditions such as Down syndrome (Trisomy 21), Edwards syndrome (Trisomy 18), and Patau syndrome (Trisomy 13).

The Double Marker Test is a screening test, not a diagnostic test. A high-risk result does not confirm that the baby has a chromosomal abnormality. Your healthcare provider may recommend further evaluation, such as NIPT or diagnostic testing like chorionic villus sampling (CVS) or amniocentesis, depending on the overall risk assessment.

This Test is Recommended for Individuals:

• Pregnant women undergoing first-trimester prenatal screening
• Expectant mothers who want early screening for chromosomal abnormalities
• Women whose healthcare provider recommends combined first-trimester screening
• Pregnant women undergoing an NT scan as part of prenatal risk assessment
• Individuals with maternal or pregnancy factors that may warrant closer chromosomal risk assessment

FAQs

1. What does the Double Marker Test check?
It measures free beta-hCG and PAPP-A in maternal blood and combines the results with other factors to estimate the risk of certain chromosomal abnormalities.

2. When is the Double Marker Test performed?
It is generally performed during the first trimester, commonly around 11 to 13+6 weeks of pregnancy, depending on the screening protocol and healthcare provider’s recommendation.

3. Does a high-risk Double Marker result mean the baby has Down syndrome?
No. The Double Marker Test is a screening test, so a high-risk result only indicates an increased probability. Additional screening or diagnostic testing may be recommended to determine the actual risk more accurately.