HE4 Human Epididymis Protein 4
The HE4 (Human Epididymis Protein 4) Test is a blood test used to measure the level of HE4 protein, a tumor marker that may be elevated in certain types of ovarian cancer.
HE4 is particularly useful in evaluating women with pelvic masses and helps differentiate between benign and malignant ovarian conditions. It is often used in combination with CA-125 and incorporated into risk assessment models such as the ROMA (Risk of Ovarian Malignancy Algorithm).
The purpose of this test is to:
- Measure HE4 protein levels in the blood
- Assist in assessing the risk of ovarian cancer
- Differentiate between benign and malignant pelvic masses
- Monitor treatment response in ovarian cancer patients
- Detect recurrence of ovarian cancer
HE4 HUMAN EPIDIDYMIS PROTEIN 4 Test
The HE4 (Human Epididymis Protein 4) test measures the level of HE4 protein in the blood. HE4 is a biomarker that can be elevated in some women with epithelial ovarian cancer, particularly certain subtypes.
The test is primarily used as an aid in monitoring women who have already been diagnosed with ovarian cancer, helping healthcare providers assess response to treatment or monitor for possible disease recurrence. It may also be used alongside other clinical assessments when evaluating an adnexal or ovarian mass.
HE4 is sometimes interpreted together with CA-125 and other clinical information. It is important to note that HE4 is not a standalone screening or diagnostic test for ovarian cancer, and an elevated result does not necessarily mean that cancer is present.
HE4 HUMAN EPIDIDYMIS PROTEIN 4 Test is Recommended for Individuals:
- Women diagnosed with epithelial ovarian cancer who require monitoring
- Patients undergoing treatment for ovarian cancer
- Women being monitored for possible recurrence after treatment
- Individuals with an ovarian or adnexal mass when HE4 testing is clinically indicated
- Patients whose healthcare provider recommends HE4 alongside CA-125 or other investigations
FAQs
1. What does the HE4 test measure?
The HE4 blood test measures the level of Human Epididymis Protein 4, a biomarker that can be elevated in certain types of epithelial ovarian cancer.
2. Can HE4 diagnose ovarian cancer?
No. HE4 alone cannot diagnose ovarian cancer. Elevated levels can occur for reasons other than cancer, and the result should be interpreted with medical history, imaging, CA-125, and other relevant investigations.
3. Why is HE4 tested along with CA-125?
HE4 and CA-125 provide different biomarker information. When appropriate, healthcare providers may consider both results together with imaging and clinical findings to help assess an ovarian mass or monitor known ovarian cancer.